Our readers keep the lights on and my morning glass full of iced black tea. As an Amazon Associate, I earn from qualifying purchases.4 Best Cream For 2nd Degree Burns | Skip the Burn Cream Hype

Check Price on Amazon

The 7.83-ounce tube gives you more product than MEBO at 0.53 ounces, and the hyaluronic acid focuses on scar prevention.

If you have a larger burn area or you want to prevent scars after a second-degree burn, this is the choice that delivers the most product for the money. At 7.83 ounces versus the MEBO tube at 0.53 ounces, you do not have to ration every drop. The formula uses hyaluronic acid (a substance that naturally holds moisture in your skin cells) paired with aloe vera to supply hydration directly to damaged tissue. Buyers report that doctors specifically recommend this gel for preventing scarring after surgery and for treating radiation burns.

Unlike thick, greasy ointments that stick to bandages, this one has a non-sticky, non-greasy texture that glides on cleanly and stays put without transferring to clothes. Owners mention it is also effective for chronic itching and radiation-induced skin irritation. The trade-off is that the stiff tube can be hard to squeeze, especially for people with arthritic hands — but the contents are worth the effort.

Check Price on Amazon

The 4 x 4-inch hydrogel pad cools on contact and stays moist without sticking to the wound — unlike the MPM gel, you leave this in place.

When you need immediate pain relief from a fresh second-degree burn, the BurnFix hydrogel dressing delivers rapid cooling right out of the package. Each pad measures 4 x 4 inches and is soaked in a soothing gel infused with Tea Tree Oil and Aloe Vera — both natural ingredients that calm the skin and help prevent infection. Unlike a cream you rub in, this is a non-adherent dressing (a pad that will not stick to the wound) you place directly on the burn and leave there, which means it stays moist without pulling at healing skin. One reviewer noted this dressing helped soothe their daughter’s burn and promoted its healing, matching the product’s design for children and facial burns.

The 4-pack gives you four individual dressings, making it easy to keep one in your home first aid kit and one in your car or camping bag. The product dimensions are 6.2 x 5.37 x 0.25 inches per pack, versus the MEBO tube at 4.33 x 1 x 1 inches. Some customers note the instructions are written in poor English, and a few mention the patches feel a bit small if you have a larger burn area. But for immediate cooling and protection, this is tough to top.

Check Price on Amazon

MEBO’s 100% herbal formula liquefies dead tissue — the manufacturer claims this “liquefaction of necrotic tissues” cleans the wound — but you get only 0.53 ounces, compared to 7.83 ounces from MPM RadiaPlex.

MEBO takes a unique approach to second-degree burn care. Instead of just moisturizing, its 100% herbal formula stimulates the discharge and removal of debris — the manufacturer calls this “liquefaction of necrotic tissues” (breaking down and flushing out dead skin cells) — so dead skin cells are cleaned out naturally. This creates an environment where bacteria and fungi cannot grow, protecting the burn from infection while new tissue forms. Reviewers point out that cuts and burns heal in one to two applications with minimal scarring.

The catch is the tube size. At 0.53 ounces with dimensions of 4.33 x 1 x 1 inches, the MEBO tube is much smaller than the MPM RadiaPlex tube at 7.83 ounces, and many shoppers say it feels overpriced — one buyer mentioned it costs about in the US but only overseas. The ointment itself has a slightly sticky feel and a sweet honey-like smell that some find pleasant and others do not. It applies smoothly and is doctor-recommended for slow-healing wounds, but for the money, you are getting a very small amount of product.

Check Price on Amazon

At 3.53 ounces and a budget-friendly price, Hametan gives you more cream than MEBO for less, but its witch hazel formula lacks the specialized burn-healing features of the top pick.

Hametan is a 30-gram cream (3.53 ounces) that uses Witch Hazel (Hamamelis virginiana) as its active ingredient. It is explicitly labeled for both first and second-degree burns, but it is also used for acne scars, nipple cracks from breastfeeding, diaper rash, bedsores, and dry chapped skin. This makes it a versatile addition to a first aid kit if you want one cream that covers many skin issues. Buyers report it absorbs quickly, is non-greasy, and effectively moisturizes dry, irritated skin all day long. One reviewer specifically said it works well for burning and itching skin.

At a budget-friendly price point, this is the cheapest option in the list and gives you a decent amount of cream (3.53 oz vs. MEBO’s 0.53 oz). The dimensions are 5.75 x 1.38 x 1.14 inches, so it fits easily in a medicine cabinet or diaper bag. However, because it is a general-purpose skin cream rather than a specialized burn treatment, it lacks the targeted features of the other products — no hyaluronic acid, no hydrogel cooling, and no liquefaction of dead tissue. For a small second-degree burn, it can work, but for anything serious, you may want a more powerful option.