Reach for digestive enzyme supplements when your gut needs targeted support, but always confirm the root cause first. For most people, a healthy pancreas already produces everything required to digest a normal meal. When that system falters—through pancreatic insufficiency or a diagnosed disorder—prescription enzymes are the gold standard, and over-the-counter options are a reasonable, lesser-supported conversation to have with your healthcare provider. Understanding your body’s own enzyme production is the first step to knowing when it needs backup. If you’re on a GLP-1 regimen and curious about supplementation, our product guide above is a practical starting point for what to consider.